Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human)) | BDBM50613663 (CHEMBL5287633) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | UniChem | n/a | n/a | 0.0500 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential M8 protein (Canis lupus familiaris (Dog)) | BDBM248583 (US9434711, 496) | PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.183 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica, N.V. US Patent | Assay Description For patch clamp experiments, HEK293 cells are stably transfected with canine TRPM8 and cultured in DMEM supplemented with 10% fetal bovine serum, 100... | US Patent US9434711 (2016) BindingDB Entry DOI: 10.7270/Q2H41QB6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily M member 8 (Rattus norvegicus (Rat)) | BDBM50465610 (CHEMBL4295040) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Salerno Curated by ChEMBL | Assay Description Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as reduction in menthol-induced channel currents by whole cell patch clamp method | J Med Chem 61: 6140-6152 (2018) Article DOI: 10.1021/acs.jmedchem.8b00545 BindingDB Entry DOI: 10.7270/Q2FN18V3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential M8 protein (Canis lupus familiaris (Dog)) | BDBM50335165 (3-[2-(1-Oxa-2-aza-spiro[4.5]dec-2-en-3-yl)-6-(2-tr...) | PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research and Development Curated by ChEMBL | Assay Description Antagonist activity at canine TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation by FLIPR assay | J Med Chem 54: 233-47 (2011) Article DOI: 10.1021/jm101075v BindingDB Entry DOI: 10.7270/Q20C4WRJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human)) | BDBM256277 (US9487488, 1) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human)) | BDBM256277 (US9487488, 1) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | 37 |
MITSUBISHI TANABE PHARMA CORPORATION US Patent | Assay Description The functional activity of a test compound was determined by measuring change in intracellular calcium concentration using a calcium sensitive fluore... | US Patent US9487488 (2016) BindingDB Entry DOI: 10.7270/Q2MG7NGT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human)) | BDBM256293 (US9487488, 17) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | 37 |
MITSUBISHI TANABE PHARMA CORPORATION US Patent | Assay Description The functional activity of a test compound was determined by measuring change in intracellular calcium concentration using a calcium sensitive fluore... | US Patent US9487488 (2016) BindingDB Entry DOI: 10.7270/Q2MG7NGT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential M8 protein (Canis lupus familiaris (Dog)) | BDBM50036555 (CHEMBL3353610 | US9434711, 497) | PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | 37 |
Janssen Pharmaceutica, N.V. US Patent | Assay Description The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi... | US Patent US9434711 (2016) BindingDB Entry DOI: 10.7270/Q2H41QB6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human)) | BDBM50335157 (3-[7-Trifluoromethyl-5-(2-trifluoromethyl-phenyl)-...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 0.413 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research and Development Curated by ChEMBL | Assay Description Inhibition of human TRPM8 expressed in HEK293 cells assessed as inhibition of cold-induced channel current by whole cell electrophysiology | J Med Chem 54: 233-47 (2011) Article DOI: 10.1021/jm101075v BindingDB Entry DOI: 10.7270/Q20C4WRJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human)) | BDBM256299 (US9487488, 23) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | 37 |
MITSUBISHI TANABE PHARMA CORPORATION US Patent | Assay Description The functional activity of a test compound was determined by measuring change in intracellular calcium concentration using a calcium sensitive fluore... | US Patent US9487488 (2016) BindingDB Entry DOI: 10.7270/Q2MG7NGT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human)) | BDBM256310 (US9487488, 34) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | 37 |
MITSUBISHI TANABE PHARMA CORPORATION US Patent | Assay Description The functional activity of a test compound was determined by measuring change in intracellular calcium concentration using a calcium sensitive fluore... | US Patent US9487488 (2016) BindingDB Entry DOI: 10.7270/Q2MG7NGT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential M8 protein (Canis lupus familiaris (Dog)) | BDBM241685 (US9409915, 89 | US9718820, Compound 89) | PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.530 | n/a | n/a | n/a | n/a | n/a | 37 |
Janssen Pharmaceutica NV US Patent | Assay Description HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM... | US Patent US9409915 (2016) BindingDB Entry DOI: 10.7270/Q23J3BVJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential M8 protein (Canis lupus familiaris (Dog)) | BDBM241685 (US9409915, 89 | US9718820, Compound 89) | PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.530 | n/a | n/a | n/a | n/a | n/a | 25 |
JANSSEN PHARMACEUTICA NV US Patent | Assay Description HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, ... | US Patent US9718820 (2017) BindingDB Entry DOI: 10.7270/Q2RV0QQ5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential M8 protein (Canis lupus familiaris (Dog)) | BDBM248583 (US9434711, 496) | PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.554 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica, N.V. US Patent | Assay Description For patch clamp experiments, HEK293 cells are stably transfected with canine TRPM8 and cultured in DMEM supplemented with 10% fetal bovine serum, 100... | US Patent US9434711 (2016) BindingDB Entry DOI: 10.7270/Q2H41QB6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential M8 protein (Canis lupus familiaris (Dog)) | BDBM241633 (US9409915, 16 | US9718820, Compound 16) | PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.590 | n/a | n/a | n/a | n/a | n/a | 37 |
Janssen Pharmaceutica NV US Patent | Assay Description HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM... | US Patent US9409915 (2016) BindingDB Entry DOI: 10.7270/Q23J3BVJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential M8 protein (Canis lupus familiaris (Dog)) | BDBM241633 (US9409915, 16 | US9718820, Compound 16) | PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.590 | n/a | n/a | n/a | n/a | n/a | 25 |
JANSSEN PHARMACEUTICA NV US Patent | Assay Description HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, ... | US Patent US9718820 (2017) BindingDB Entry DOI: 10.7270/Q2RV0QQ5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential M8 protein (Canis lupus familiaris (Dog)) | BDBM248576 (US9434711, 489) | PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | 37 |
Janssen Pharmaceutica, N.V. US Patent | Assay Description The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi... | US Patent US9434711 (2016) BindingDB Entry DOI: 10.7270/Q2H41QB6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential M8 protein (Canis lupus familiaris (Dog)) | BDBM248370 (US9434711, 227) | PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | 37 |
Janssen Pharmaceutica, N.V. US Patent | Assay Description The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi... | US Patent US9434711 (2016) BindingDB Entry DOI: 10.7270/Q2H41QB6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human)) | BDBM151765 (US8987445, 201) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | 37 |
Mitsubishi Tanabe Pharma Corporation US Patent | Assay Description The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy... | US Patent US8987445 (2015) BindingDB Entry DOI: 10.7270/Q2BZ64R5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential M8 protein (Canis lupus familiaris (Dog)) | BDBM50335170 (3-[5-(2-Fluoro-6-trifluoromethylphenyl)-1H-benzimi...) | PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research and Development Curated by ChEMBL | Assay Description Antagonist activity at canine TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation by FLIPR assay | J Med Chem 54: 233-47 (2011) Article DOI: 10.1021/jm101075v BindingDB Entry DOI: 10.7270/Q20C4WRJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human)) | BDBM256298 (US9487488, 22) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | 37 |
MITSUBISHI TANABE PHARMA CORPORATION US Patent | Assay Description The functional activity of a test compound was determined by measuring change in intracellular calcium concentration using a calcium sensitive fluore... | US Patent US9487488 (2016) BindingDB Entry DOI: 10.7270/Q2MG7NGT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential M8 protein (Canis lupus familiaris (Dog)) | BDBM241638 (US9409915, 21 | US9718820, Compound 21) | PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.690 | n/a | n/a | n/a | n/a | n/a | 25 |
JANSSEN PHARMACEUTICA NV US Patent | Assay Description HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, ... | US Patent US9718820 (2017) BindingDB Entry DOI: 10.7270/Q2RV0QQ5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential M8 protein (Canis lupus familiaris (Dog)) | BDBM241638 (US9409915, 21 | US9718820, Compound 21) | PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.690 | n/a | n/a | n/a | n/a | n/a | 37 |
Janssen Pharmaceutica NV US Patent | Assay Description HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM... | US Patent US9409915 (2016) BindingDB Entry DOI: 10.7270/Q23J3BVJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential M8 protein (Canis lupus familiaris (Dog)) | BDBM50335160 (2-(1-Oxa-2-aza-spiro[4.5]dec-2-en-3-yl)-6-(2-trifl...) | PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research and Development Curated by ChEMBL | Assay Description Antagonist activity at canine TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation by FLIPR assay | J Med Chem 54: 233-47 (2011) Article DOI: 10.1021/jm101075v BindingDB Entry DOI: 10.7270/Q20C4WRJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human)) | BDBM256301 (US9487488, 25) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | 37 |
MITSUBISHI TANABE PHARMA CORPORATION US Patent | Assay Description The functional activity of a test compound was determined by measuring change in intracellular calcium concentration using a calcium sensitive fluore... | US Patent US9487488 (2016) BindingDB Entry DOI: 10.7270/Q2MG7NGT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential M8 protein (Canis lupus familiaris (Dog)) | BDBM248599 (US9434711, 518) | PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | 37 |
Janssen Pharmaceutica, N.V. US Patent | Assay Description The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi... | US Patent US9434711 (2016) BindingDB Entry DOI: 10.7270/Q2H41QB6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human)) | BDBM256290 (US9487488, 14) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | 37 |
MITSUBISHI TANABE PHARMA CORPORATION US Patent | Assay Description The functional activity of a test compound was determined by measuring change in intracellular calcium concentration using a calcium sensitive fluore... | US Patent US9487488 (2016) BindingDB Entry DOI: 10.7270/Q2MG7NGT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human)) | BDBM256314 (US9487488, 38) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | 37 |
MITSUBISHI TANABE PHARMA CORPORATION US Patent | Assay Description The functional activity of a test compound was determined by measuring change in intracellular calcium concentration using a calcium sensitive fluore... | US Patent US9487488 (2016) BindingDB Entry DOI: 10.7270/Q2MG7NGT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential M8 protein (Canis lupus familiaris (Dog)) | BDBM248838 (US9434711, 808) | PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | 37 |
Janssen Pharmaceutica, N.V. US Patent | Assay Description The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi... | US Patent US9434711 (2016) BindingDB Entry DOI: 10.7270/Q2H41QB6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human)) | BDBM256278 (US9487488, 2) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | 37 |
MITSUBISHI TANABE PHARMA CORPORATION US Patent | Assay Description The functional activity of a test compound was determined by measuring change in intracellular calcium concentration using a calcium sensitive fluore... | US Patent US9487488 (2016) BindingDB Entry DOI: 10.7270/Q2MG7NGT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential M8 protein (Canis lupus familiaris (Dog)) | BDBM241686 (US9409915, 90 | US9718820, Compound 90) | PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.730 | n/a | n/a | n/a | n/a | n/a | 37 |
Janssen Pharmaceutica NV US Patent | Assay Description HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM... | US Patent US9409915 (2016) BindingDB Entry DOI: 10.7270/Q23J3BVJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential M8 protein (Canis lupus familiaris (Dog)) | BDBM241686 (US9409915, 90 | US9718820, Compound 90) | PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.730 | n/a | n/a | n/a | n/a | n/a | 25 |
JANSSEN PHARMACEUTICA NV US Patent | Assay Description HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, ... | US Patent US9718820 (2017) BindingDB Entry DOI: 10.7270/Q2RV0QQ5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential M8 protein (Canis lupus familiaris (Dog)) | BDBM248480 (US9434711, 361) | PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | 37 |
Janssen Pharmaceutica, N.V. US Patent | Assay Description The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi... | US Patent US9434711 (2016) BindingDB Entry DOI: 10.7270/Q2H41QB6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human)) | BDBM256303 (US9487488, 27) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | 37 |
MITSUBISHI TANABE PHARMA CORPORATION US Patent | Assay Description The functional activity of a test compound was determined by measuring change in intracellular calcium concentration using a calcium sensitive fluore... | US Patent US9487488 (2016) BindingDB Entry DOI: 10.7270/Q2MG7NGT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential M8 protein (Canis lupus familiaris (Dog)) | BDBM248580 (US9434711, 493) | PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | 37 |
Janssen Pharmaceutica, N.V. US Patent | Assay Description The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi... | US Patent US9434711 (2016) BindingDB Entry DOI: 10.7270/Q2H41QB6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human)) | BDBM50335157 (3-[7-Trifluoromethyl-5-(2-trifluoromethyl-phenyl)-...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential M8 protein (Canis lupus familiaris (Dog)) | BDBM248583 (US9434711, 496) | PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | 37 |
Janssen Pharmaceutica, N.V. US Patent | Assay Description The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi... | US Patent US9434711 (2016) BindingDB Entry DOI: 10.7270/Q2H41QB6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential M8 protein (Canis lupus familiaris (Dog)) | BDBM50426573 (CHEMBL2324349 | US9434711, 306) | PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | 37 |
Janssen Pharmaceutica, N.V. US Patent | Assay Description The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi... | US Patent US9434711 (2016) BindingDB Entry DOI: 10.7270/Q2H41QB6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human)) | BDBM151774 (US8987445, 210) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | 37 |
Mitsubishi Tanabe Pharma Corporation US Patent | Assay Description The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy... | US Patent US8987445 (2015) BindingDB Entry DOI: 10.7270/Q2BZ64R5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential M8 protein (Canis lupus familiaris (Dog)) | BDBM50335157 (3-[7-Trifluoromethyl-5-(2-trifluoromethyl-phenyl)-...) | PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research and Development Curated by ChEMBL | Assay Description Antagonist activity at canine TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation by FLIPR assay | J Med Chem 54: 233-47 (2011) Article DOI: 10.1021/jm101075v BindingDB Entry DOI: 10.7270/Q20C4WRJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential M8 protein (Canis lupus familiaris (Dog)) | BDBM50335171 (3-[5-(2-Fluoro-6-trifluoromethoxyphenyl)-1H-benzim...) | PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research and Development Curated by ChEMBL | Assay Description Antagonist activity at canine TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation by FLIPR assay | J Med Chem 54: 233-47 (2011) Article DOI: 10.1021/jm101075v BindingDB Entry DOI: 10.7270/Q20C4WRJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential M8 protein (Canis lupus familiaris (Dog)) | BDBM248426 (US9434711, 292) | PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | 37 |
Janssen Pharmaceutica, N.V. US Patent | Assay Description The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi... | US Patent US9434711 (2016) BindingDB Entry DOI: 10.7270/Q2H41QB6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential M8 protein (Canis lupus familiaris (Dog)) | BDBM241636 (US9409915, 19 | US9718820, Compound 19) | PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.840 | n/a | n/a | n/a | n/a | n/a | 37 |
Janssen Pharmaceutica NV US Patent | Assay Description HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM... | US Patent US9409915 (2016) BindingDB Entry DOI: 10.7270/Q23J3BVJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential M8 protein (Canis lupus familiaris (Dog)) | BDBM241636 (US9409915, 19 | US9718820, Compound 19) | PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.840 | n/a | n/a | n/a | n/a | n/a | 25 |
JANSSEN PHARMACEUTICA NV US Patent | Assay Description HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, ... | US Patent US9718820 (2017) BindingDB Entry DOI: 10.7270/Q2RV0QQ5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential M8 protein (Canis lupus familiaris (Dog)) | BDBM248789 (US9434711, 755) | PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | 37 |
Janssen Pharmaceutica, N.V. US Patent | Assay Description The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi... | US Patent US9434711 (2016) BindingDB Entry DOI: 10.7270/Q2H41QB6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human)) | BDBM151677 (US8987445, 104) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | MCE PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | 37 |
Mitsubishi Tanabe Pharma Corporation US Patent | Assay Description The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy... | US Patent US8987445 (2015) BindingDB Entry DOI: 10.7270/Q2BZ64R5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential M8 protein (Canis lupus familiaris (Dog)) | BDBM248581 (US9434711, 494) | PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | 37 |
Janssen Pharmaceutica, N.V. US Patent | Assay Description The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi... | US Patent US9434711 (2016) BindingDB Entry DOI: 10.7270/Q2H41QB6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential M8 protein (Canis lupus familiaris (Dog)) | BDBM248389 (US9434711, 249) | PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | 37 |
Janssen Pharmaceutica, N.V. US Patent | Assay Description The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi... | US Patent US9434711 (2016) BindingDB Entry DOI: 10.7270/Q2H41QB6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human)) | BDBM256294 (US9487488, 18) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | 37 |
MITSUBISHI TANABE PHARMA CORPORATION US Patent | Assay Description The functional activity of a test compound was determined by measuring change in intracellular calcium concentration using a calcium sensitive fluore... | US Patent US9487488 (2016) BindingDB Entry DOI: 10.7270/Q2MG7NGT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human)) | BDBM151797 (US8987445, 233) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | 37 |
Mitsubishi Tanabe Pharma Corporation US Patent | Assay Description The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy... | US Patent US8987445 (2015) BindingDB Entry DOI: 10.7270/Q2BZ64R5 | |||||||||||
More data for this Ligand-Target Pair |
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